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In 1840 Leidy began his study of medicine under Dr. James McClintock, then a private teacher of anatomy. The following year Leidy received instruction in the use of the microscope from Paul B. Goddard at the University of Pennsylvania. After McClintock moved to Vermont in 1842, Goddard became Leidy's preceptor. In 1844, after three sessions in Penn's Medical School, Leidy submitted his thesis on "The Comparative Anatomy of the Eye of Vertebrated Animals." Immediately
after his 1844 graduation from Penn's Medical School, Joseph Leidy began the practice
of medicine as his father demanded him to do. However His rise was rapid and his output prodigious, quickly establishing Leidy as the foremost microscopist in America and the founder of American vertebrate paleontology. During his lifetime, he published over eight hundred scientific articles. His research included descriptive work on the evidence of fossils that proved horses has existed and become extinct in America long before they were reintroduced by the Spanish. He examined many fossils found in the American West to discover many extinct species, and also assembled the first fairly complete dinosaur skeleton from bones found in New Jersey. Even before Darwin's writing, Leidy described the disappearance of old species and the appearance of new species as well as of variations within a species. When Darwin published his theory of evolution and natural selection in 1859, Leidy quickly became a supporter. He saw the relationships between fossil skeletons, but did not publish the taxonomy of these animals as it related to evolutionary thinking; that would be done by younger men, Othniel Charles Marsh and Edward Drinker Cope. Much of Leidy's work had direct bearing on medical practice. These studies focused not just on descriptive human anatomy but also on such varied subjects as the transplantation of fragments of human cancer to a frog, the identification of Trichina larvae in pork and the necessity of further cooking of meat, the existence of small plant and animal organisms on many animal species (even humans). Leidy may even have been the first to use the microscope in forensic medicine when he examined blood on the shirt of an accused murderer to demonstrate that, since the red blood cells were not nucleated, the blood was definitely not that of a chicken as claimed but instead possible that of a human. Leidy's skills and knowledge led to multiple appointments in educational and scientific institutions. In 1853, upon the retirement of William Horner, Leidy became professor of anatomy in the University of Pennsylvania; he would teach Penn's medical students for 38 years, and his 1861 anatomy textbook became the standard anatomical text for medical students for decades. Until 1872 the University of Pennsylvania was located at its Ninth Street campus, just below Market Street. Here Leidy had two dissecting rooms on the second floor of Medical Hall, adjacent to the museum, lecture and student dissecting rooms. At one time or another he was involved with such medical institutions as Franklin Medical College, St. Joseph's Hospital, and during the Civil War, Satterlee Military Hospital.
Not surprisingly, Leidy became the first president of the American Association of Anatomists in 1888 and 1889. He was a member of more than fifty societies, including the American Philosophical Society and the College of Philadelphia, and the recipient of many medals and honors, including the medal of the Royal Microscopical Society and the Cuvier Medal from the Academy of Sciences in Paris. He rarely, however, attended meetings away from Philadelphia. Joseph Leidy in 1864 married Anna, the daughter of Robert Harden of Louisville, Kentucky. They had an adopted daughter, Allie, and lived near Thirteenth and Filbert Streets in the center of Philadelphia. Joseph Leidy died at home on April 30, 1891.
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